向孟清(Xiang, Mengqing)
向孟清(Xiang,Mengqing)博士 教授 博士生导师
教育&科研经历
1981-1985，中山大学生物系，获理学学士学位，并考取吴瑞（CUSBEA）留学项目
1986-1991，美国德克萨斯大学休斯顿健康科学中心，MD安德森癌症中心生物化学及分子生物学系，获博士学位
1991-1996，美国约翰.霍普金斯大学医学院分子生物及遗传学系，霍华德.休斯医学研究所，博士后
1996–2002，美国罗格斯大学，罗伯特.伍德.约翰逊医学院儿科系，助理教授
2002–2006，美国罗格斯大学，罗伯特.伍德.约翰逊医学院儿科系，终身副教授
2006-2013，美国罗格斯大学，罗伯特.伍德.约翰逊医学院儿科系，终身教授
1996–2013，美国罗格斯大学，高级生物技术及医学中心，分子神经发育实验室主任和常驻教研员
1997–2013，美国罗格斯大学，新泽西癌症研究所，研究员
2013-至今，中山大学中山眼科中心，眼科学国家重点实验室，教授、博士生导师
主要学术任职情况
广东省医学领军人才，中山眼科中心眼科学国家重点实验室课题组组长。长期从事神经发育与再生方面的研究，集中于探索视网膜神经元的特化、分化以及成活的分子机理和基因调控网络、建立视网膜变性疾病的动物模型、以及从干细胞和成纤维细胞诱导分化出视网膜/神经细胞用于视网膜/神经系统的修复和再生，在视网膜与感觉神经发育等研究领域处于世界领先地位。获得过多项荣誉和奖励，其中包括Basil O’Connor起步学者研究奖，Sinsheimer学者奖，Wolf, Block, Schorr and Solis-Cohen, LLP听觉科学奖等。承担或参与973计划、国家重点研发计划、国家自然科学基金创新群体项目等多项课题。已在Neuron、Science Advances、Nature Communications、PNAS等期刊上发表相关论文80余篇，代表性文章被Neuron、Nature Communications、Nat Rev Neurosci和J Neurosci选为研究亮点或封面而予以专文评述。担任Frontiers in Neuroscience/Neurology/Genetics副主编以及Science, Nature Communications, PNAS, Cell Reports, eLife等数十个国际期刊审搞人。
代表性论文
1) Xiang, M., Zhou, L., Peng, Y.-W., Eddy, R. L., Shows, T. B., and Nathans, J. (1993) Brn-3b: a POU-domain gene expressed in a subset of retinal ganglion cells. Neuron 11:689-701.
2) Gan, L., Xiang, M.*, Zhou, L., Wagner, D., Klein, W. H., and Nathans, J. (1996) POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells. Proc. Natl. Acad. Sci. USA 93:3920-3925. (*Co-first author).
3) Xiang, M., Gan, L., Zhou, L., Klein, W. H., and Nathans, J. (1996) Targeted deletion of the mouse POU domain gene Brn-3a causes a selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling. Proc. Natl. Acad. Sci. USA 93:11950-11955.
4) Xiang, M., Zhou, H., and Nathans, J. (1996) Molecular biology of retinal ganglion cells. Proc. Natl. Acad. Sci. USA. 93:596-601.
5) Xiang, M., Gan, L., Li, D., Chen, Z.-Y., Zhou, L., O’Malley, B. W., Klein, W. H., and Nathans, J. (1997) Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Proc. Natl. Acad. Sci. USA 94:9445-9450.
6) Liu, W., Mo, Z., and Xiang, M. (2001) The Ath5 proneural genes function upstream of Brn3 POU domain transcription factor genes to promote retinal ganglion cell development. Proc. Natl. Acad. Sci. USA 98:1649-1654.
7) Li, S., Mo, Z., Yang, X., Price, S. M., Shen, M. M., and Xiang, M. (2004) Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors. Neuron 43:795-807
8) Li, S., Misra, K., Matise, M., and Xiang, M. (2005) Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord. Proc. Natl. Acad. Sci. USA 102:10688-10693.
9) Jiang, H. and Xiang, M. (2009) Subtype specification of GABAergic amacrine cells by the orphan nuclear receptor Nr4a2/Nurr1. J. Neurosci. 29:10449-10459.
10) Jin, K., Jiang, H., Mo, Z., and Xiang, M. (2010) Early B-cell factors are required for specifying multiple retinal cell types and subtypes from postmitotic precursors. J. Neurosci. 30:11902-11916.
11) Luo, H., Jin, K., Xie, Z., Qiu, F., Li, S., Zou, M., Cai, L., Hozumi, K., Shima, D. T., and Xiang, M. (2012) Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors. Proc. Natl. Acad. Sci. USA 109:E553-E562.
12) Misra, K., Luo, H., Li, S., Matise, M., and Xiang, M. (2014) Asymmetric activation of Dll4-Notch signaling by Foxn4 and proneural factors activates BMP/TGFb signaling to specify V2b interneurons in the spinal cord. Development 141:187-198.
13) Hu, W., Li, S., Park, J.Y., Boppana, S., Ni, T., Li, M., Zhu, J., Tian, B., Xie, Z., and Xiang, M. (2017) Dynamic landscape of alternative polyadenylation during retinal development. Cell. Mol. Life Sci. 74:1721-1739.
14) Cheng, L., Lei, Q., Jin, K., and Xiang, M. (2017) Generation of urine cell-derived non-integrative human iPSCs and iNSCs: a step-by-step optimized protocol. Front. Mol. Neurosci. 10:348.
15) Xiao, D., Liu, X., Zhang, M., Zou, M., Deng, Q., Sun, D., Bian, X., Cai, Y., Guo, Y., Liu, S., Li, S., Shiang, E., Zhong, H., Cheng, L., Xu, H., Jin, K., and Xiang, M. (2018) Direct reprogramming of fibroblasts into neural stem cells by single nonneural progenitor transcription factor Ptf1a. Nat. Commun. 9:2865.
16) Xiao, D., Jin, K., and Xiang, M. (2018) Necessity and sufficiency of Ldb1 in the generation, differentiation and maintenance of non-photoreceptor cell types during retinal development. Front. Mol. Neurosci. 11:271.
17) Wei, W., Liu, B., Jiang, H., Jin, K., and Xiang, M. (2019) Requirement of the Mowat-Wilson syndrome gene Zeb2 in the differentiation and maintenance of non-photoreceptor cell types during retinal development. Mol. Neurobiol. 56:1719-1736.
18) Jin, K. and Xiang, M. (2019) Transcription factor Ptf1a in development, diseases and reprogramming. Cell. Mol. Life Sci. 76:921-940.
19) Liu, S., Liu, X., Li, S., Huang, X., Qian, H., Jin, K., and Xiang, M. (2020) Foxn4 is a temporal identity factor conferring mid/late-early retinal competence and involved in retinal synaptogenesis. Proc. Natl. Acad. Sci. USA 117:5016-5027.
20) Xiao, D., Deng, Q., Guo, Y., Huang, X., Zou, M., Zhong, J., Rao, P., Xu, Z., Liu, Y., Hu, Y., Shen, Y., Jin, K., and Xiang M. (2020) Generation of self-organized sensory ganglion organoids and retinal ganglion cells from fibroblasts. Sci. Adv. 6:eaaz5858.