钟秀风(Zhong, Xiufeng)
教授，研究员, 副主任医师，博士生导师
中山大学中山眼科中心 眼科学国家重点实验室课题组长
研究方向：
1.新一代hPSC-ROs系统开发及药筛；
2.退行性视网膜疾病的遗传机制及基因治疗；
3.干细胞治疗神经致盲眼病的临床转化
E-mail: zhongxf7@mail.sysu.edu.cn
Tel：020-87334327
地址：广东省广州市先烈南路54,510060
教育与工作经历
1986 - 1991 南昌大学医学部（江西医学院医疗系）医学学士
1991 - 1998 南昌大学第一附属医院 住院医师/主治医师/讲师
1998 - 2001 中山医科大学中山眼科中心 医学硕士
2001 - 2005 中山大学中山眼科中心 主治医师/讲师
2006 - 2010 中山大学中山眼科中心 临床型副研/硕导
2003 - 2006 中山大学中山眼科中心 医学博士
2009 - 2016 美国约翰霍普金斯大学医学院 眼科系/Wilmer眼科研究所 博士后/访问科学家
2014 - 至今 中山大学中山眼科中心 入选中大“百人计划” 研究员／博导/教授/副主任医师
主要学术任职情况
中山大学“百人计划”引进干细胞方向“急需人才”，中山大学中山眼科中心国家重点实验室课题组组长。美国眼科与视觉研究协会等专业学会会员，是Ophthalmology，IOVS, Stem Cells International等国际期刊审稿人,是Stem Cells International的guest editor 和《中华细胞与干细胞杂志》编委；是中国解剖学会血管分会委员，中华医学会医学工程学分会第八届委员会干细胞工程学组委员，广东省细胞治疗学会委员；广东省精准医学应用学会类器官学组副组长，是英国MRC基金的评审专家、科技部重点研发、国家自然科学基金、广东省科技计划项目等函评与会评专家。
长期从事眼科临床、教学与科研工作。熟悉眼科常见病多发病的诊治，对罕见及疑难视网膜疾病具有独到见解，熟悉眼科疾病的临床病理诊断。在干细胞与视网膜疾病研究方向做了长期而系统的研究工作，取得了原创性成果：1）在国际上首次揭示人视网膜母细胞瘤(Rb)肿瘤干细胞，为Rb发病机制、转移及防治研究提供了新理论与靶点；2）在国际上首次用人多能干细胞（hPSC）培育出有“光反应”功能的视网膜类器官（RO），这些hPSC-ROs高度模拟了人类视网膜的形态发生和细胞、组织架构，解决了人类视网膜疾病防治研究中视网膜组织缺乏的瓶颈问题，提供了全新的研究平台。研究成果发表同行评议文章80多篇，总引用超过1300次，参编书籍2部。授权专利15项，其中PCT1项；得到Nature，US News & World Report, the Scientist等媒体报道；受邀在国内外专题会议和著名大学讲座。承担了科技部重点研发、国家自然科学基金、省市科技计划重点项目等十多项。
发表文章（选）：
1. Guan Y, Wang Y, Zheng D, Xie B, Xu P, Gao G and Zhong X (2022) Generation of an RCVRN-eGFP Reporter hiPSC Line by CRISPR/Cas9 to Monitor Photoreceptor Cell Development and Facilitate the Cell Enrichment for Transplantation. Front. Cell Dev. Biol. 10:870441. doi: 10.3389/fcell.2022.870441
2. Yuanyuan Guan#, Bingbing Xie, Xiufeng Zhong. Retinal Organoid Induction System for Derivation of 3D Retinal Tissues from Human Pluripotent Stem Cells. J Vis Exp. 2021 Apr 12;(170). doi: 10.3791/62435.
3. Guanjie Gao, Liwen He, Shengxu Liu, Dandan Zheng, Xiaojing Song, Wenxin Zhang, Minzhong Yu, Guangwei Luo and Xiufeng Zhong. Establishment of a Rapid Lesion-Controllable Retinal Degeneration Monkey Model for Preclinical Stem Cell Therapy. Cells. 2020, 9: 2468
4. Li G, Gao G, Wang P, Song X, Xu P, Xie B, Zhou T, Pan G, Peng F, Zhang Q, Ge J, Zhong X. Generation and Characterization of Induced Pluripotent Stem Cells and Retinal Organoids From a Leber's Congenital Amaurosis Patient With Novel RPE65 Mutations. Front Mol Neurosci. 2019 Sep 11;12:212. doi: 10.3389/fnmol.2019.00212. eCollection 2019 IF 5.639 , ISSN 1662-5099
5. Liu S, Xie B, Song X, Zheng D, He L, Li G, Gao G, Peng F, Yu M, Ge J, Zhong X. Self-Formation of RPE Spheroids Facilitates Enrichment and Expansion of hiPSC-Derived RPE Generated on Retinal Organoid Induction Platform. Invest Ophthalmol Vis Sci. 2018 Nov 1; 59(13):5659-5669. doi: 10.1167/ ISSN 0146-0404 IF 3.812
6. Luo Z, Zhong X*, Li K, Xie B, Liu Y, Ye M, Li K, Xu C, Ge J. An Optimized System for Effective Derivation of Three-Dimensional Retinal Tissue via Wnt Signaling Regulation. Stem Cells. 2018 Nov;36(11):1709-1722. IF 5.614 ISSN 1066-5099
7. Guilan Li, Bingbing Xie, Liwen He, Tiancheng Zhou, Guanjie Gao, Shengxu Liu, Guangjin Pan, Jian Ge, Fuhua Peng, and Xiufeng Zhong. Generation of Retinal Organoids with Mature Rods and Cones from Urine-Derived Human Induced Pluripotent Stem Cells. Stem Cells International. 2018, Article ID 4968658, https://doi.org/10.1155/2018/4968658
8. Bell WR, Meeker AK, Rizzo A, Rajpara S, Rosenthal IM, Flores Bellver M, Aparicio Domingo S, Zhong X, Barber JR, Joshu CE, Canto-Soler MV, Eberhart CG, Heaphy CM. A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease. Brain Pathol. 2018, doi: 10.1111/bpa.12618.
9. Kang Li, Shengxu Liu, Xiufeng Zhong, Jian Ge. Generation of an acute retinal photoreceptor degeneration model in rabbits. Am J Transl Res. 2018; 10: 235–245.
10. Yi H, Xie B, Liu B, Wang X, Xu L, Liu J, Li M, Zhong X, Peng F. Derivation and Identification of Motor Neurons from Human Urine-Derived Induced Pluripotent Stem Cells. Stem Cells Int. 2018:3628578. doi: 10.1155/2018/3628578. eCollection 2018.
11. Li K, Zhong X, Yang S, Luo Z, Li K, Liu Y, Cai S, Gu H, Lu S, Zhang H, Wei Y, Zhuang J, Zhuo Y, Fan Z, Ge J. HiPSC-derived retinal ganglion cells grow dendritic arbors and functional axons on a tissue-engineered scaffold. Acta Biomater. 2017 Feb 16. pii: S1742-7061(17)30137-X. doi: 10.1016/j.actbio.2017.02.032.
12. Zimmerlin L, Park TS, Huo JS, Verma K, Pather SR, Talbot CC Jr, Agarwal J, Steppan D, Zhang YW, Considine M, Guo H, Zhong X, Gutierrez C, Cope L, Canto-Soler MV, Friedman AD, Baylin SB, Zambidis ET. Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality. Development. 2016 Dec 1;143 (23):4368-4380.
13. Zhong X, Gutierrez C, Xue T, Hampton C, Vergara MN, Cao LH, Peters A, Park TS, Zambidis ET, Meyer JS, Gamm DM, Yau KW, Canto-Soler MV. Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs. Nature Communications. Nat Commun. 2014 Jun 10; 5:4047. doi: 10.1038/ncomms5047.
14. Liu Y, Zhong X, Wan S, Zhang W, Lin J, Zhang P, Li Y. p16 INK4a expression in retinoblastoma: a marker of differentiation grade. Diagnostic Pathology，2014，9（1）：180-180
15. Phillips MJ, Wallace KA, Dickerson SJ, Miller MJ, Verhoeven AD, Martin JM, Wright LS, Shen W, Capowski EE, Percin EF, Perez ET, Zhong X, Canto-Soler MV, Gamm DM. Blood-derived Human iPS Cells Generate Optic Vesicle-like Structures with the Capacity to Form Retinal Laminae and Develop Synapses. Invest Ophthalmol Vis Sci. 2012 Apr 18;53(4):2007-19
16. Zhong X, Huang H, Shen J, Zacchigna S, Zentilin L, Giacca M, Vinores SA. VEGF-B gene transfer exacerbates retinal and choroidal neovascularization and vasopermeability without promoting inflammation. Molecular Vision 2011; 17:492-507
17. Zhong X, Li Y, Peng F, Huang B, Lin J, Zhang W, Zheng J, Jiang R, Song G, Ge J. Identification of tumorigenic retinal stem-like cells in human solid retinoblastomas. Int. J. Cancer, 2007, 121: 2125
媒体报道（选）：
1）Research Highlight by Nature Publishing Group: Stem cells: From human stem cells to light-sensing retinas （http://www.natureasia.com/en/research/highlight/9313 ）
2）Johns Hopkins Medicine: Human stem cells to create light sensitive retina in a dish
3）The Scientist: (http://www.the-scientist.com/?articles.view/articleNo/40169/title/Light-Sensing-Retina-in-a-Dish/)
4）US News & World Report：Human stem cells used to create light sensitive eye cells
5）WBALTV：http://www.wbaltv.com/health/johns-hopkins-researchers-create-lightsensitive-retina/26639354#!4taCN