李旭日（Li, Xuri）

李旭日(Xuri, Li) 博士，教授，博士生导师

中山大学中山眼科中心，眼科学国家重点实验室副主任

研究方向：血管生物学

电子邮件(E-mail )：lixr6@mail.sysu.edu.cn

电话 (Tel) ：020-66619344

邮政编码：510060

English Personal Homepage: www.zocangio.org/html/principal_investigators/Xuri%20Li.html

工作经历：

1988 – 1993，上海医科大学（现复旦大学上海医学院），助教

1997 – 2000，瑞典卡罗林斯卡研究院，博士后

2001 – 2004，比利时鲁汶大学，博士后

2004 – 2005，瑞典卡罗林斯卡研究院，助理研究员

2005 – 2012，美国国立卫生院国立眼研究所，研究室主任，

首席科学家 (Principal Investigator)

2012 – 至今，中山大学中山眼科中心，教授，眼科学国家重点实验室副主任

简介

李旭日教授为广东省“创新领军人才”，广东省医学领军人才，眼科学国家重点实验室副主任，中山大学领军人才，亚太血管生物学协会（APVBO）创始人。2005-2012年于美国国立卫生院眼研究所(NIH/NEI)任研究室主任，首席科学家(Principal Investigator)。2012底率其美国NIH/NEI团队骨干成员集体全职加盟中山大学中山眼科中心，创建了包括来自韩国、瑞典、印度和中国科学家的国际化眼血管神经生物学实验室。李旭日教授长期从事血管生物学研究，为血小板源性生长因子PDGF-C/PDGF-D的发现者，在血管生物学领域居国际前沿，在Nature、Science、Cell Metabolism、J Clin Invest、J Exp Med、PNAS 等发表论文103篇。

眼血管生物学实验室：www.zocangio.org/

亚太血管生物学协会：www.apvbo.org/html/Mission_Statement.html

代表论著

1. Kalucka, J., de Rooij, Lpmh, Goveia, J., Rohlenova, K., Dumas, S. J., Meta, E., Conchinha, N. V., Taverna, F., Teuwen, L. A., Veys, K., Garcı´a-Caballero, M., Khan, S., Geldhof, V., Sokol, L., Chen, R., Treps, L., Borri, M., de Zeeuw, P., Dubois,C., Karakach, T. K., Falkenberg, K. D., Parys, M., Yin, X., Vinckier, S., Du, Y., Fenton, R. A., Schoonjans, L., Dewerchin, M., Eelen, G., Thienpont, B., Lin, L., Bolund, L., Xuri Li*, Luo, Y.,* & Carmeliet, P.*, Single-Cell Transcriptome Atlas of Murine Endothelial Cells, Cell, 180(4): 764-779 e20, 2020

2. Rohlenova, K., Goveia, J., Garcia-Caballero, M., Subramanian, A., Kalucka, J., Treps, L., Falkenberg, K. D., de Rooij, Lpmh, Zheng, Y., Lin, L., Sokol, L., Teuwen, L. A., Geldhof, V., Taverna, F., Pircher, A., Conradi, L. C., Khan, S., Stegen, S., Panovska, D., De Smet, F., Staal, F. J. T., McLaughlin, R. J., Vinckier, S., Van Bergen, T., Ectors, N., De Haes, P., Wang, J., Bolund, L., Schoonjans, L., Karakach, T. K., Yang, H., Carmeliet, G., Liu, Y., Thienpont, B., Dewerchin, M., Eelen, G., Xuri Li*, Luo, Y.,* & Carmeliet, P.*, Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis, Cell Metab, 31(4): 862-877 e14, April, 2020

3. Xuri Li*, Carmeliet, P.*, Endothelial cell metabolism in angiogenesis, Science, 359(6382):1335-1336, 2018

4. Arjunan, P., Lin, X., Tang, Z., Du, Y., Kumar, A., Liu, L., Yin, X., Huang, L., Chen, W., Chen, Q., Ye, Z., Wang, S., Kuang, H., Zhou, L., Xu, K., Chen, X., Zeng, H., Lu, W., Cao, Y., Liu, Y., Zhao, C.*, Xuri Li*, VEGF-B is a potent antioxidant, Proc Natl Acad Sci U S A, 115(41): 10351-10356, 2018

5. Jiang, Y., Lin, X., Tang, Z., Lee, C., Tian, G., Du, Y., Yin, X., Ren, X., Huang, L., Ye, Z., Chen, W., Zhang, F., Mi, J., Gao, Z., Wang, S., Chen, Q., Xing, L., B. Wang, Y. Cao, W. C. Sessa, R. Ju*, Y. Liu*, Xuri Li*, Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK, Proc Natl Acad Sci U S A, 114(40): 10737-10742, 2017

6. He, C., Zhao, C., Kumar, A., Lee, C., Chen, M., Huang, L., Wang, J., Ren, X., Jiang, Y., Chen, W., Wang, B., Gao, Z., Zhong, Z., Huang, Z., Zhang, F., Huang, B., Ding, H., Ju, R., Tang, Z., Liu, Y., Cao, Y., Xuri Li*, Liu, X*., Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration, Proc Natl Acad Sci U S A, 111(41):14806-11, 2014

7. Hou, X., Kumar, A., Lee, C., Wang, B., Arjunan, P., Dong, L., Maminishkis, A., Tang, T., Li, Y., Zhang, F., Zhang, S-Z., Wardega, P., Chakrabarty, S., Liu, B., Wu, Z., Colosi, P., Fariss, R. N., Lennartsson, J., Nussenblatt, R., Gutkind, J. S., Cao, Y., Xuri Li*, PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets, Proc Natl Acad Sci USA, 107(27):12216-12221, 2010

8. Tang, Z., Arjunan, P., Lee, C., Li, Y., Kumar, A., Hou, X., Wang, B., Wardega, P., Zhang, F., Dong, L., Zhang, Y., Zhang, S. Z., Ding, H., Fariss, R. N., Becker, K. G., Lennartsson, J., Nagai, N., Cao, Y., Xuri Li*, Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation, J Exp Med, 207(4):867-880, 2010

9. Zhang, F., Tang, Z., Hou, X., Lennartsson, J., Li, Y., Koch, A. W., Scotney, P., Lee, C., Arjunan, P., Dong, L., Kumar, A., Rissanen, T. T., Wang, B., Nagai, N., Fons, P., Fariss, R., Zhang, Y., Wawrousek, E., Tansey, G., Raber, J., Fong, G. H., Ding, H., Greenberg, D. A., Becker, K. G., Herbert, J. M., Nash, A., Yla-Herttuala, S., Watts, R. J., Xuri Li*, VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis, Proc Natl Acad Sci USA, 106(15):6152-6157, 2009

10. Li, Y., Zhang, F., Nagai, N., Tang, Z., Zhang, S., Scotney, P., Lennartsson, J., Zhu, C., Qu, Y., Fang, C., Hua, J., Matsuo, O., Fong, G. H., Ding, H., Cao, Y., Becker, K. G., Nash, A., Heldin, C. H., Xuri Li*, VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats, J Clin Invest, 118(3):913–923, 2008

11. Xuri Li, Ponten A., Aase K., Linda K., Abramsson A., Uutela M., Backman G., Hellstrom M., Bostrom H., Li H., Betsholtz C., Heldin C. H., Alitalo K., Ostman A. & Eriksson U. PDGF-C is a new protease-activated ligand for the PDGF-a receptor, Nat Cell Biol, 2(5):302-309, 2000