柯江滨(Ke, Jiangbin)
柯江滨(Ke,Jiangbin) 博士 研究员 博士生导师
中山大学中山眼科中心 眼科学国家重点实验室 课题组长
研究方向:视网膜神经环路的细胞组成、功能及调控;
视网膜疾病中的神经保护研究
电子邮件:kejiangbin@mail.sysu.edu.cn
联系地址:广东省广州市越秀区先烈南路54号
中山眼科中心柯江滨课题组
邮政编码:510060
简历
1999 – 2003 复旦大学,生物科学,学士
2003 – 2009 复旦大学,神经生物学,博士
2009 – 2016 美国弗吉尼亚大学/西北大学/马里兰大学,助理研究员
2016至今 中山大学中山眼科中心,研究员
研究组工作摘要
目前实验室的主要兴趣在于,应用双电极膜片钳记录、光遗传学、药理学、病毒示踪、免疫组化、电镜及分子生物学等多种技术方法,探索视网膜神经元之间如何精确地组成神经环路以处理和传递特定的视觉信息,并希望通过研究病理条件下视网膜神经环路的结构和功能异常,进一步探讨视网膜相关疾病的发病机理及可能的诊断和治疗方法。柯江滨博士具有多年视网膜/神经科学领域相关研究经验,以往的部分研究结果改变了我们对视杆(夜间视觉)信号传导的传统认识。目前已在Neuron、The Journal of Neuroscience、Cell Reports、eLife、Neuroscience和eNeuro等神经科学领域的国际知名杂志上发表多篇学术论文。
已发表的代表性学术论文(#Co-first authors; *Co-corresponding authors)
1. Liang CQ#, Zhang G#, Zhang L, Chen SY, Wang JN, Zhang TT, Singer JH*, Ke JB*. Calmodulin bidirectionally regulates evoked and spontaneous neurotransmitter release at retinal ribbon synapses. eNeuro, 2021, 8(1): ENEURO.0257-20.2020.
2. Park SJH#, Lieberman EE#, Ke JB, Rho N, Ghorbani P, Rahmani P, Jun AY, Lee HL, Kim IJ, Briggman KL, Demb JB*, Singer JH*. Connectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision. eLife, 2020, 9: e56077.
3. Park SJH#, Pottackal J#, Ke JB, Jun NY, Rahmani P, Kim IJ, Singer JH, Demb JB. Convergence and divergence of CRH amacrine cells in mouse retinal circuitry. The Journal of Neuroscience, 2018, 38(15): 3753-3766.
4. Mortensen LS#, Park SJH#, Ke JB, Cooper BH, Zhang L, Imig C, Lowel S, Reim K, Brose N, Demb JB, Rhee JS*, Singer JH*. Complexin 3 increases the fidelity of signaling in a retinal circuit by regulating exocytosis at ribbon synapses. Cell Reports, 2016, 15(10): 2239-50.
5. Firl A, Ke JB, Zhang L, Fuerst PG, Singer JH*, Feller MB*. Elucidating the role of AII amacrine cells in glutamatergic retinal waves. The Journal of Neuroscience, 2015, 35(4): 1675-1684.
6. Ke JB#, Wang YV#, Borghuis BG, Cembrowski MS, Riecke H, Kath WL, Demb JB*, Singer JH*. Adaptation to background light enables contrast coding at rod bipolar cell synapses. Neuron, 2014, 81(2): 388-401.
7. Mehta B#, Ke JB#, Zhang L, Baden AD, Markowitz AL, Nayak S, Briggman KL, Zenisek D*, Singer JH*. Global Ca2+ signaling drives ribbon-independent synaptic transmission at rod bipolar cell synapses. The Journal of Neuroscience, 2014, 34(18): 6233-6244.
8. Chen W#, Ke JB#, Wu HJ, Miao Y, Li F, Yang XL, Wang Z. Somatostatin receptor-mediated suppression of GABAergic synaptic transmission in cultured rat retinal amacrine cells. Neuroscience, 2014, 273: 118-127.
9. Ke JB#, Chen W#, Yang XL, Wang Z. Characterization of spontaneous inhibitory postsynaptic currents in cultured rat retinal amacrine cells. Neuroscience, 2010, 165: 395-407.
10. Ke JB, Zhong YM. Expression of somatostatin receptor subtype 5 in rat retinal amacrine cells. Neuroscience, 2007, 144: 1025-1032.