刘春巧(Liu, Chunqiao)

刘春巧(Liu, Chunqiao)博士 研究员 博士生导师

中山大学中山眼科中心   眼科学国家重点实验室  课题组负责人

研究方向: 发育神经生物学

电子邮件(E-mail ):liuchunq3@mail.sysu.edu.cn

电话(Tel) :86-020-87333749

邮政编码 :510060

English Personal Homepage

简历 & 研究组工作摘要

1995-1998 中国科学院遗传与发育生物学研究所 博士

1999-2000 美国国家癌症所 访问学者

2001-2003 卡耐基研究所胚胎学系 博士后

2003-2008 约翰霍普金斯大学医学院 博士后

2008-2011 美国国家眼科所 高级研究学者(外聘,Title 42)

2011-2015 美国国家眼科所 高级研究科学家(PI-track,Title 42,)

2015-至今 中山大学中山眼科中心 高级研究员

主要学术任职情况

研究方向:

1)视网膜神经发生和相关遗传疾病

我们的研究表明,Wnt信号通路在视网膜神经发生和眼发育疾病中扮演了重要角色。Wnt-Frizzled对视网膜神经上皮完整性的保持是必需的。失去Frizzled受体会导致视网膜神经上皮顶极粘着连接缺陷(Liu et al., 2012),影响视网膜神经母细胞接受其他号通路(比如Notch信号)的能力。目前有待探究的问题有:1)哪一个Wnt配基在视网膜发育中起主要作用;2)Wnt配基来源于何种组织;3)参与视网膜前体细胞的极性建立的Wnt-frizzled-5信号通路下游组件是什么; 4)Wnt-frizzled-5信号的异常是如何导致晚期光感受体细胞变性的。回答这些问题将进一步拓展人们对Wnt信号通路异常引起的视网膜病变的机理以及细胞信号通路在疾病过程中相互作用关系的认识,为发展有效临床治疗手段提供指导。

2)视网膜神经通路和视觉通路的发育和联接机制

视网膜神经通路和视觉通路的发育和联接机制是视觉神经生物学的本质内容,涉及神经元形态发生,突触连接的目标识别和选择以及轴突和树突的修剪(prunning)。我们最近的研究表明,Wnt/PCP信号通路的其中一个组件—Prickle对脑皮质神经元和光感细胞的树突和轴突的发生至关重要(Liu et al., 2013)。在非神经组织中,Prickle1 通过控制Dvl2的磷酸化阻截Wnt5a信号通路(Liu et al., 2014)。我们猜测Wnt5a/Prickle1/Dvl2模式在眼神经元回路的构建过程中也起到类似的作用,相关验证工作正在进行。

3)视网膜变性和再生机理

视网膜变性和再生是今年的研究热点。许多色素性视网膜炎(Retinitis pigmentosa, RP)、老年黄斑变性(age-related macular degeneration, AMD)患者都存在光感受细胞营养障碍和变性,导致视力逐渐丧失。目前,这些疾病没有有效的治愈方法。我们正致力于厘清视网膜变性的疾病机理,创造一些遗传学工具,同时从事新药发现的药物筛选研究,为视觉恢复提供治疗手段。我们正在利用iPSCs和CRISPR几项先进的技术,结合基因编辑和细胞治疗,在‘精准医疗’的框架内发展新的治疗策略。

主要学术组织任职情况

学术编委: Journal of Neurology & Translational Neuroscience

学会会员:Association for Research in Vision and Ophthalmology (ARVO),American Society for Cell Biology (ASCB),Society for Developmental Biology (SDB), Society for Neuroscience (SfN)

应邀审稿人:PLoS One, Molecular Vision, Journal of Neurology & Translational Neuroscience,Clinical Ophthalmology,IOVS (Investigative Ophthalmology & Visual Science),Aging Cell, Journal of clinical investigation,The Journal of Neuroscience, Developmental Biology, Developmental Dynamics, Development, Human Molecular Genetics.

国际会议应邀报告:The 31th Asia-Pacific Academy of Ophthalmology Congress (APAO), Taipei, 2016The 30th Asia-Pacific Academy of Ophthalmology Congress (APAO), Guangzhou, 20154th International Conference on Clinical & Experimental Ophthalmology,Baltimore, 2014 Cold Spring Harbor conference (Asia) on “Stem Cell and Developmental Biology”, Suzhou China, 2012ARVO (Association for Research in Vision and Ophthalmology) annual meeting, Florida, 2009 National Eye Institute (NEI), Neurobiology-Neurodegeneration & Repair Symposium, 2008SDB (Society for Developmental Biology) 59th annual meeting, Boulder,20017th Annual Joint Scientific Symposium of the NIH/FDA Chinese American Association (CAA), and the Washington DC Chapter of Society of Chinese Bioscientists in America (SCBA),Washington DC, 2000

发表文章(选):

1.Sharda Prasad Yadav1*, Neel Kamal Sharma1, Chunqiao Liu1#, Lijin Dong2Tiansen Li1* and Anand Swaroop* (2016) Centrosomal protein CP110 controls maturation of mother centriole during cilia biogenesis. Development (provisionally accepted)

2.Chunqiao Liu, Sonya A. Widen3#, Kathleen A. Williamson4#, Rinki Ratnapriya1, Christina Gerth-Kahlert5 et al., (2016). A Secreted WNT-Ligand Binding Domain of FZD5 Generated by a Frameshift Mutation Causes Autosomal Dominant Coloboma. Human Molecular Genetics doi: 10.1093/hmg/ddw020

3.Chunqiao Liu*, Chen Lin, Chun Gao, Helen May-Simera, Anand Swaroop *, Tiansen Li* (2014). Null and hypomorph Prickle1 alleles in mice phenocopy human Robinow syndrome and disrupt signaling downstream of Wnt5a. Biol Open 3:861-870 (Corresponding author*)

4.Helen May-Simera and Chunqiao Liu* (2013) (Editorial) Neuronal Polarity and Neurological Disorders. J Neurol Transl Neurosci 2(1): 1026 (Corresponding author*)

5.Chunqiao Liu*, Chen Lin, D. Thad Whitaker, Hirva Bakeri, Oleg V Bulgakov, Pinghu Liu, Jingqi Lei, Lijin Dong, Tiansen Li, and Anand Swaroop* (2013). Prickle1 is expressed in distinct cell populations of the central nervous system and contributes to neuronal morphogenesis. Human Molecular Genetics 22: 2234-2246 (Cover of the issue, Corresponding author*)

6.Chunqiao Liu*, Hirva Bakeri, Tiansen Li Anand Swaroop* (2012). Regulation of retinal progenitor expansion by Frizzled receptors: Implications for microphthalmia and retinal coloboma. Human Molecular Genetics 21: 1848-1860 (Cover of the issue, Corresponding author*)

7.Senthil S. Saravanamuthu, Tien T. Le, Chun Y. Gao, Radu I. Cojocaru, Pushpa Pandiyan, Chunqiao Liu, Jun Zhang, Peggy S. Zelenka, Nadean L. Brown (2012). Conditional ablation of the Notch2 receptor in the ocular lens. Developmental Biology 362-219-229

8.James S. Friedman, Bo Chang, Daniel S. Krauth, Irma Lopez, Naushin H. Waseem, Ron E. Hurd, Kecia L. Feather, Kari E. Branham, Manessa Shaw, George E. Thomas, Matthew J. Brooks, Chunqiao Liu, Hirva A. Bakeri ,Maria M. Campos, Cecilia Maubaret, Andrew R. Webster, Ignacio R. Rodriguez, Debra A. Thompson, Shomi S. Bhattacharya, Robert K. Koenekoop, John R. Heckenlively, and Anand Swaroop (2011). Loss of lysophosphatidylcholine acyltransferase 1 leads to photoreceptor degeneration in rd11 mice. Proc Natl Acad Sci 107:15523-155289.Chunqiao Liu, and Jeremy Nathans (2008). An essential role of Frizzled 5 in the mammalian ocular development: loss of Frizzled5 leads to microphthalmia, delayed closure of the optic fissure, persistence of the hyloid vasculature, and a late retinal degeneration. Development 135: 3567-3576

10.Chunqiao Liu, Yanshu Wang, Philip M. Smallwood and Jeremy Nathans (2008). An Essential Role for Frizzled5 in Neuronal Survival in the Parafascicular Nucleus of the Thalamus. The Journal of Neuroscience 22:5641-5653 (Highlighted in “ the week of the journal”)

11.Chunqiao Liu, Aynslee Well, and Chen-ming Fan (2003). Identification of the Downstream Targets of SIM1 and ARNT2, a Pair of Transcription Factors Essential for Neuroendocrine Cell Differentiation. The Journal of Biological Chemistry 278: 44857-44867

12.Chunqiao Liu, Vladimir Knezecic, Susan Mackem (2004). Ventral Tail Bud Mesenchyme Is a Signaling Center for Tail Paraxial Mesoderm Induction. Developmental Dynamics 229: 600-606

13.Chunqiao Liu, Eiichiro Nakamura, Vladimir Knezecic, Sherrie Hunter, Katherime Thompson, Susan Mackem (2003). A role for the mesenchymal T-box gene Brachyury in AER formation during limb development. Development 130: 1327-1337

14.Ying Liu, Chunqiao Liu, Yoshihiko Yamada and Chen-Ming Fan (2002). growth arrest specific 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb. Development 129: 5289-530

专著和章节:

1.李云龙主编,刘春巧,李广鹏参编(2011),《发育和进化》,中国科学出版社

2.刘春巧,李云龙主编(2003),动物发育生物学,山东科技出版社

3.黄秀英,孙方臻等译《发育生物学》(Werner A.Muller著)高教出版社

4.周琪,刘春巧,霍妍理(1997),《神秘的克隆》教育科学出版社


资料来源:刘春巧         网页更新:2016.3